Springer-Verlag New York Inc. Acoustics Of Musical Instruments
257.59 GBP
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This book, the first English-language translation of Acoustique des instruments de musique, Second Edition, presents the necessary foundations for understanding the complex physical phenomena involved in musical instruments.What is the function of the labium in a flute? Which features of an instrument allow us to make a clear audible distinction between a clarinet and a trumpet?With the help of numerous examples, these questions are addressed in detail.The authors focus in particular on the significant results obtained in the field during the last fifteen years.Their goal is to show that elementary physical models can be used with benefit for various applications in sound synthesis, instrument making, and sound recording.The book is primarily addressed to graduate students and researchers; however it could also be of interest for engineers, musicians, craftsmen, and music lovers who wish to learn about the basics of musical acoustics.
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Springer-Verlag New York Inc. Ultrastructure Of Endocrine Cells And Tissues
41.39 GBP
Innovative microscopic techniques, introduced during the last two decades, have contributed much to creating a new picture of the dynamic architecture of the cell, which can now be more exactly correlated with specific biochemical and physiopathological events.These developments have led to significant advances in our understanding of the physiomorphological and pathological aspects of the secretory mechanism, as well as the pharmacologic methods used to control, experimentally, the function of exocrine and endocrine glands.The integration of new ultrastructural methods such as freeze-fracture/etching, immunocytochemistry, scanning and high-voltage electron microscopy, cytoautoradiography, etc. , has proven to be of great value when applied to the study of endocrine cells and tissues. Because information on this topic has appeared in a variety of scientific and medical journals, this book: (1) reviews the results of an integrative approach presenting a comprehensive ultrastructural account of the main aspects of the field; (2) points out gaps or controversial topics in our knowledge; and (3) outlines pertinent directions for future research.The chapters, prepared by recognized authorities in the field, present traditional information on the topic in a concise manner and, with a valuable selection of original illustrations, show what the integration of new microscopic methods can contribute to the subject in terms of new concepts.This volume will be useful to cell biologists, anatomists, embryologists, histologists, pharmacologists, pathologists, and, of course, endocrinologists.It will also be of interest to students, practitioners of medicine, and to all others dealing with clinical research and diagnosis.
Springer-Verlag New York Inc. Proteomics In Systems Biology : Methods And Protocols
183.99 GBP
This detailed book highlights the diverse techniques and applications of proteomics in an accessible, informative, and concise manner.The collection features sample preparation from distinct extraction, quantification, enrichment, modification, as well as interactome methodology for the in-depth exploration of biological systems, and the application of proteomics to clinical, infectious disease, and agricultural practices.Moreover, cutting-edge bioinformatics tools, encompassing machine learning and data integration strategies, are explored, as are techniques expanding beyond proteomics into the realm of metabolomics.Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting known pitfalls.Comprehensive and practical, Proteomics in Systems Biology:Methods and Protocols emphasizes the importance of proteomics and demonstrates a plethora of approaches for investigating diverse biological entities from a systems perspective.
Springer-Verlag New York Inc. Basic Business Statistics : A Casebook
64.86 GBP
Preface Statistics is seldom the most eagerly anticipated course of a business student.It typically has the reputation of being a boring, complicated, and confusing mix of mathematical formulas and computers.Our goal in writing this cas and the companion volume (Business Analysis Using Regression) was to change that impression by showing how statistics yields insights and answers interesting business questions.Rather than dwell on underlying formulas, we show how to use statistics to answer questions.Each case study begins with a business question and concludes with an answer to that question.Formulas appear only as needed to address the questions, and we focus on the insights into the problem provided by the mathematics.The mathematics serves a purpose. The material in this cas is organized into 11 "classes" of related case studies that develop a single, key idea of statistics.The analysis of data using statistics is seldom very straightforward, and each analysis has many nuances.Part of the appeal of statistics is this richness, this blending of substantive theories and mathematics.For newcomers, however, this blend is too rich, and they are easily overwhelmed and unable to sort out the important ideas from nuances.Although later cases in these notes suggest this complexity, we do not begin that way.
Springer-Verlag New York Inc. Russia'S Cosmonauts : Inside The Yuri Gagarin Training Center
27.59 GBP
With the aid of unique photographs, first-hand interviews and historical resources, Rex Hall, Dave Shayler and Bert Vis explain, for the very first time, how Russian citizens have been selected and trained to fly in space, and how these procedures have changed during the past 40 years.The authors also describe the evolution of the often overlooked ground support infrastructure and how the role of cosmonauts has changed from the very earliest days of the Gagarin era, through the demise of the Soviet Union, to the era of international co-operation and collaboration on programmes such as the International Space Station. The book will provide much important background information and insight to the operational Soviet/Russian manned space programme, already covered in other Springer-Praxis titles, but revealing information and facts not covered elsewhere, and providing a unique reference source for all those who wish to understand the changing role of Russian cosmonauts in today’s global space programme.
Springer-Verlag New York Inc. Introducing Monte Carlo Methods With R
55.19 GBP
Computational techniques based on simulation have now become an essential part of the statistician's toolbox.It is thus crucial to provide statisticians with a practical understanding of those methods, and there is no better way to develop intuition and skills for simulation than to use simulation to solve statistical problems.Introducing Monte Carlo Methods with R covers the main tools used in statistical simulation from a programmer's point of view, explaining the R implementation of each simulation technique and providing the output for better understanding and comparison.While this book constitutes a comprehensive treatment of simulation methods, the theoretical justification of those methods has been considerably reduced, compared with Robert and Casella (2004).Similarly, the more exploratory and less stable solutions are not covered here. This book does not require a preliminary exposure to the R programming language or to Monte Carlo methods, nor an advanced mathematical background.While many examples are set within a Bayesian framework, advanced expertise in Bayesian statistics is not required.The book covers basic random generation algorithms, Monte Carlo techniques for integration and optimization, convergence diagnoses, Markov chain Monte Carlo methods, including Metropolis {Hastings and Gibbs algorithms, and adaptive algorithms.All chapters include exercises and all R programs are available as an R package called mcsm.The book appeals to anyone with a practical interest in simulation methods but no previous exposure.It is meant to be useful for students and practitioners in areas such as statistics, signal processing, communications engineering, control theory, econometrics, finance and more.The programming parts are introduced progressively to be accessible to any reader.
Springer-Verlag New York Inc. Naive Lie Theory
34.03 GBP
In this new textbook, acclaimed author John Stillwell presents a lucid introduction to Lie theory suitable for junior and senior level undergraduates.In order to achieve this, he focuses on the so-called "classical groups'' that capture the symmetries of real, complex, and quaternion spaces.These symmetry groups may be represented by matrices, which allows them to be studied by elementary methods from calculus and linear algebra. This naive approach to Lie theory is originally due to von Neumann, and it is now possible to streamline it by using standard results of undergraduate mathematics.To compensate for the limitations of the naive approach, end of chapter discussions introduce important results beyond those proved in the book, as part of an informal sketch of Lie theory and its history. John Stillwell is Professor of Mathematics at the University of San Francisco.He is the author of several highly regarded books published by Springer, including The Four Pillars of Geometry (2005), Elements of Number Theory (2003), Mathematics and Its History (Second Edition, 2002), Numbers and Geometry (1998) and Elements of Algebra (1994).
Springer-Verlag New York Inc. Hormonal Carcinogenesis Ii : Proceedings Of The Second International Symposium
41.39 GBP
For those of us who have labored in the field of hormonal carcinogenesis, it has been most gratifying to see its rapid growth and increasing relevance in recent years.Although many factors and forces have contributed to this phenomenon, a few appear particularly significant.Perhaps foremost is the realization that two of the most prevalent cancers which afflict women and men; that is, breast and prostate, have essential hormonal component(s) to their etiologies.This should not surprise us since the high frequency of these cancers in human populations has to date not been attributed to any exogenous physical, environmental, or dietary factor(s).A similar argument may be applied to other less prevalent but equally important cancers including ovarian, endometrial, testicular, cervico- vaginal, pituitary, thyroid, and sex hormone-associated hepatic neoplasms.The Office of Research on Women's Health and many women's interest groups have been instrumental in fostering research and public awareness on women's cancers.Similar concern is beginning to emerge for solely male cancers by other groups. To illustrate an example of the potential pervasive role of hormones in the human, particularly sex hormones, Figure I depicts the endogenous and known exogenous exposures to estrogens and progestins during a woman's lifetime, which may contribute to increased risk for hormonally-associated cancers . . = iii M. A. P. _ GI en 2 PoOlmenopauoal ~ EstrogDn ~ Proge. tln GI en J Ovulatory _ 2 Cyel. iii W DES EIP Menotr". 1 Ol,order.
Springer-Verlag New York Inc. Hilbert Space Operators In Quantum Physics
101.19 GBP
Almost ?fteen years later, and there is little change in our motivation.Mathem- ical physics of quantum systems remains a lively subject of intrinsic interest with numerous applications, both actual and potential.Intheprefacetothe?rsteditionwehavedescribedtheoriginofthisbookrooted at the beginning in a course of lectures.With this fact in mind, we were naturally pleased to learn that the volume was used as a course text in many points of the world and we gladly accepted the o?er ofSpringer Verlag which inherited the rights from our original publisher, to consider preparation of a second edition.It was our ambition to bring the reader close to the places where real life dwells, and therefore this edition had to be more than a corrected printing.The ?eld is developing rapidly and since the ?rst edition various new subjects have appeared; as a couple of examples let us mention quantum computing or the major progress in theinvestigationofrandomSchr. odingeroperators.Thereare,however,goodsources intheliteraturewherethereadercanlearnabouttheseandothernewdevelopments.
Springer-Verlag New York Inc. Explanatory Item Response Models : A Generalized Linear And Nonlinear Approach
147.19 GBP
This edited volume gives a new and integrated introduction to item re sponse models (predominantly used in measurement applications in psy chology, education, and other social science areas) from the viewpoint of the statistical theory of generalized linear and nonlinear mixed models.Moreover, this new framework aHows the domain of item response mod els to be co-ordinated and broadened to emphasize their explanatory uses beyond their standard descriptive uses.The basic explanatory principle is that item responses can be modeled as a function of predictors of various kinds.The predictors can be (a) char acteristics of items, of persons, and of combinations of persons and items; they can be (b) observed or latent (of either items or persons); and they can be (c) latent continuous or latent categorical.Thus, a broad range of models can be generated, including a wide range of extant item response models as weH as some new ones.Within this range, models with explana tory predictors are given special attention, but we also discuss descriptive models.Note that the 'item responses' that we are referring to are not just the traditional 'test data,' but are broadly conceived as categorical data from a repeated observations design.Hence, data from studies with repeated-observations experimental designs, or with longitudinal designs, mayaIso be modeled.The intended audience for this volume is rather broad.
Springer-Verlag New York Inc. Biodiversity : Biomolecular Aspects Of Biodiversity And Innovative Utilization
41.39 GBP
Proceedings of the 3rd IUPAC International Conference on Biodiversity (ICOB-3), November 3-8, 2001, Antalya, Turkey.This book discusses the value of bioresources and the need for their conservation in terms of the biomolecular chemistry of naturally occurring molecular systems.The development of pharmaceutical, agricultural and industrial products from bioresources can be used to promote incentives for conservation by providing an economic return to sustainable use of those sources.The 54 chapters inform readers on the search for insight into the species and documents how much of life remains to be scientifically identified.They also explore identification strategies and methods along with the implications for protecting biodiversity.In summary, biomolecular aspects of biodiversity and innovative utilization of bioresources are discussed from very diverse points of view ranging from their botanical, zoological, taxonomic and genomic expressions to their biomolecular, structural, mechanistic and functional aspects.
Springer-Verlag New York Inc. The Scientific Correspondence Of H.A. Lorentz : Volume I
184.92 GBP
This volume presents a selection of 434 letters from and to the Dutch physicist and Nobel Prize winner Hendrik Antoon Lorentz (1853–1928), covering the period from 1883 until a few months before his death in February 1928.The sheer size of the available correspondence (approximately 6000 letters from and to Lorentz) preclude a full publication.The letters included in this volume have been selected according to various criteria, the most important of which is scientific importance.A second criterion has been the availability of letters both from and to Lorentz, so that the reader can follow the exchange between Lorentz and his correspondent.Within such correspondences a few unimportant items, dealing with routine administrative or organizational matters, have been omitted.An exception to the scientific criterion is the exchange of letters between Lorentz and Albert Einstein, Max Planck, Woldemar Voigt, and Wilhelm Wien during World War I: these letters have been included because they shed important light on the disruption of the scientific relations during the war and on the political views of these correspondents as well as of Lorentz. similar reasons the letters exchanged with Einstein and Planck on post-war political issues have been included.Biographical sketch Hendrik Antoon Lorentz was born on July 18, 1853 in the Dutch town of Arnhem.He was the son of a relatively well-to-do owner of a nursery.
Springer-Verlag New York Inc. Brute Force : Cracking The Data Encryption Standard
26.98 GBP
In the 1960s, it became increasingly clear that more and more information was going to be stored on computers, not on pieces of paper.With these changes in technology and the ways it was used came a need to protect both the systems and the information.For the next ten years, encryption systems of varying strengths were developed, but none proved to be rigorous enough.In 1973, the NBS put out an open call for a new, stronger encryption system that would become the new federal standard.Several years later, IBM responded with a system called Lucifer that came to simply be known as DES (data encryption standard). The strength of an encryption system is best measured by the attacks it is able to withstand, and because DES was the federal standard, many tried to test its limits. (It should also be noted that a number of cryptographers and computer scientists told the NSA that DES was not nearly strong enough and would be easily hacked.) Rogue hackers, usually out to steal as much information as possible, tried to break DES.A number of "white hat" hackers also tested the system and reported on their successes.Still others attacked DES because they believed it had outlived its effectiveness and was becoming increasingly vulnerable.The sum total of these efforts to use all of the possible keys to break DES over time made for a brute force attack. In 1996, the supposedly uncrackable DES was broken.In this captivating and intriguing book, Matt Curtin charts DES’s rise and fall and chronicles the efforts of those who were determined to master it.
Springer-Verlag New York Inc. Methods Of Cell Separation
41.39 GBP
Presently, the need for methods involving separation, identification, and characterization of different kinds of cells is amply realized among immu nologists, hematologists, cell biologists, clinical pathologists, and cancer researchers.Unless cells exhibiting different functions and stages of differ entiation are separated from one another, it will be exceedingly difficult to study some of the molecular mechanisms involved in cell recognition, spe cialization, interactions, cytotoxicity, and transformation.Clinical diagno sis of diseased states and use of isolated cells for therapeutic (e. g. , immu notherapy) or survival (e. g, transfusion) purposes are some of the pressing areas where immediate practical benefits can be obtained by applying cell separation techniques.However, the development of such useful methods is still in its infancy.A number of good techniques exist based either on the physical or biological properties of the cells, and these have produced some valuable results.Still others are to be discovered. Therefore, the purpose of this open-ended treatise is to acquaint the reader with some of the basic principles, instrumentation, and procedures presently in practice at various laboratories around the world and to present some typical applications of each technique to particular biological problems.
Springer-Verlag New York Inc. Geometry
32.19 GBP
This text is the fifth and final in the series of educational books written by Israel Gelfand with his colleagues for high school students.These books cover the basics of mathematics in a clear and simple format – the style Gelfand was known for internationally.Gelfand prepared these materials so as to be suitable for independent studies, thus allowing students to learn and practice the material at their own pace without a class. Geometry takes a different approach to presenting basic geometry for high-school students and others new to the subject. Rather than following the traditional axiomatic method that emphasizes formulae and logical deduction, it focuses on geometric constructions.Illustrations and problems are abundant throughout, and readers are encouraged to draw figures and “move” them in the plane, allowing them to develop and enhance their geometrical vision, imagination, and creativity.Chapters are structured so that only certain operations and the instruments to perform these operations are available for drawing objects and figures on the plane.This structure corresponds to presenting, sequentially, projective, affine, symplectic, and Euclidean geometries, all the while ensuring students have the necessary tools to follow along. Geometry is suitable for a large audience, which includes not only high school geometry students, but also teachers and anyone else interested in improving their geometrical vision and intuition, skills useful in many professions.Similarly, experienced mathematicians can appreciate the book’s unique way of presenting plane geometry in a simple form while adhering to its depth and rigor. “Gelfand was a great mathematician and also a great teacher.The book provides an atypical view of geometry. Gelfand gets to the intuitive core of geometry, to the phenomena of shapes and how they move in the plane, leadingus to a better understanding of what coordinate geometry and axiomatic geometry seek to describe.” - Mark Saul, PhD, Executive Director, Julia Robinson Mathematics Festival“The subject matter is presented as intuitive, interesting and fun. No previous knowledge of the subject is required. Starting from the simplest concepts and by inculcating in the reader the use of visualization skills, [and] after reading the explanations and working through the examples, you will be able to confidently tackle the interesting problems posed. I highly recommend the book to any person interested in this fascinating branch of mathematics.” - Ricardo Gorrin, a student of the Extended Gelfand Correspondence Program in Mathematics (EGCPM)
Springer-Verlag New York Inc. Coping With Physical Illness : 2: Perspectives
41.39 GBP
This book provides new ideas about how patients and their fami lies cope with serious health crises.Biomedical knowledge has expanded abruptly in the past decade during which time diag nostic and treatment procedures have become unusually specific and effective.Similarly, important advances have taken place in our understanding of the central role of psychosocial factors in health and illness.Recent trends have sparked the formulation of useful concepts of coping skills and social resources and have empha sized the value of an active assertive role for patients in the pro cess of obtaining health care.The emergence of subspecialties such as behavioral medicine and health psychology has stimulated renewed interest in these areas.Moreover, the growth of holistic medicine and a biopsychosocial orientation highlights the contri bution of a psychosocial perspective in an integrated framework for providing health care.To cover these diverse trends, I offer a unified conceptual approach for understanding the process of coping with the crisis of physical illness and identifying the underlying adaptive tasks and domains of coping skills involved in this process.The first half of the book covers coping with selected health crises, such as birth defects and perinatal death, childhood and adult cancer, and chronic physical disabilities.
Springer-Verlag New York Inc. The Biosphere
27.59 GBP
Long unknown in the West, The Biosphere established the field of biogeochemistry and is one of the classic founding documents of what later became known as Gaia theory.It is the first sustained expression of the idea that life is a geological force that can change Earth's landforms, its climate, and even the contents of its atmosphere.A complete, unabridged translation has never before been available in English.This edition - complete with extensive annotations, an introductory essay placing the work in its historical context and explaining its relevance to readers today, and a foreword cosigned by a stellar group of international experts - will be the definitive edition of this classic work. "What Darwin did for life through time, Vernadsky did for life through space on a geological scale".
Springer-Verlag New York Inc. Alcoholism And Clinical Psychiatry
41.39 GBP
It is well known that alcoholism continues to be one of this country's major public health problems.This issue is carefully documented by Dr. Gerald Klerman, Chief of ADAMHA, in the second chapter ofthis volume.In spite of the major role that alcohol plays in the health care issues of internal medicine, neurology, and psychiatry, the subject continues to fall between the cracks of the various disciplines.For this reason, it has become almost a discipline of its own; yet there are no academic departments of alcoholism because academic departments are unidisciplinary and alcoholism is clearly a multidisciplinary field within medicine.In spite of the many disciplines involved in the study and treatment of alcoholism, psychiatry continues to have a special, albeit often neglected, relationship to alcoholism, and it is the articulation ofthat relationship which prompted the Department of Psychiatry at the Downstate Medical Center to organize the conference upon which many chapters in this volume are based.Particular emphasis in selecting the topics to be covered was placed on the interface between alcoholism and clinical psychiatry, including affective disorders, schizophrenia, suicide, adolescence, the special problems of women, and psychotherapy, to mention only some of them.
Springer-Verlag New York Inc. Divestitures And Spin-Offs : Lessons Learned In The Trenches Of The World’s Largest M&a Deals
91.99 GBP
The world of M&A has always been complex and nuanced.Corporations encounter their toughest business problems during a divestiture or a merger.At the same time, optimal execution of divestitures can also create high value for the seller as well as the buyer.This book is a collection of leading practices on Divestitures and covers end to end transaction life cycle from readiness through execution including post deal transformation.It contains the synthesis of experiences across a wide array of clients across industries, ranging from $500 million to $100 billion in revenue. Each chapter in this book can stand on its own as an authority on leading practices related to the topic it presents, and together, these chapters provide a comprehensive set of perspectives needed to successfully complete a divestiture.The highlight of the book is valuable real-life examples and references that a business can benefit from, when it is considering, analyzing or implementing a divestiture.
Springer-Verlag New York Inc. Handbook Of Response To Intervention : The Science And Practice Of Multi-Tiered Systems Of Support
321.99 GBP
The Second Edition of this essential handbook provides a comprehensive, updated overview of the science that informs best practices for the implementation of response to intervention (RTI) processes within Multi-Tiered Systems of Support (MTSS) to facilitate the academic success of all students.The volume includes insights from leading scholars and scientist-practitioners to provide a highly usable guide to the essentials of RTI assessment and identification as well as research-based interventions for improving students’ reading, writing, oral, and math skills.New and revised chapters explore crucial issues, define key concepts, identify topics warranting further study, and address real-world questions regarding implementation. Key topics include:Scientific foundations of RTIPsychometric measurement within RTIRTI and social behavior skillsThe role of consultation in RTIMonitoring response to supplemental servicesUsing technology to facilitate RTIRTI and transition planningLessons learned from RTI programs around the countryThe Second Edition of the Handbook of Response to Intervention is an essential resource for researchers, graduate students, and professionals/scientist-practitioners in child and school psychology, special and general education, social work and counseling, and educational policy and politics.
Springer-Verlag New York Inc. Functions Of One Complex Variable I
41.39 GBP
This book is intended as a textbook for a first course in the theory of functions of one complex variable for students who are mathematically mature enough to understand and execute E - 8 arguments.The actual pre requisites for reading this book are quite minimal; not much more than a stiff course in basic calculus and a few facts about partial derivatives.The topics from advanced calculus that are used (e.g., Leibniz's rule for differ entiating under the integral sign) are proved in detail.Complex Variables is a subject which has something for all mathematicians.In addition to having applications to other parts of analysis, it can rightly claim to be an ancestor of many areas of mathematics (e.g., homotopy theory, manifolds).This view of Complex Analysis as "An Introduction to Mathe matics" has influenced the writing and selection of subject matter for this book.The other guiding principle followed is that all definitions, theorems, etc.
Springer-Verlag New York Inc. Principles Of Systems Science
55.19 GBP
This pioneering text provides a comprehensive introduction to systems structure, function, and modeling as applied in all fields of science and engineering.Systems understanding is increasingly recognized as a key to a more holistic education and greater problem solving skills, and is also reflected in the trend toward interdisciplinary approaches to research on complex phenomena.While the concepts and components of systems science will continue to be distributed throughout the various disciplines, undergraduate degree programs in systems science are also being developed, including at the authors’ own institutions.However, the subject is approached, systems science as a basis for understanding the components and drivers of phenomena at all scales should be viewed with the same importance as a traditional liberal arts education. Principles of Systems Science contains many graphs, illustrations, side bars, examples, and problems to enhance understanding.Frombasic principles of organization, complexity, abstract representations, and behavior (dynamics) to deeper aspects such as the relations between information, knowledge, computation, and system control, to higher order aspects such as auto-organization, emergence and evolution, the book provides an integrated perspective on the comprehensive nature of systems.It ends with practical aspects such as systems analysis, computer modeling, and systems engineering that demonstrate how the knowledge of systems can be used to solve problems in the real world.Each chapter is broken into parts beginning with qualitative descriptions that stand alone for students who have taken intermediate algebra.The second part presents quantitative descriptions that are based on pre-calculus and advanced algebra, providing a more formal treatment for students who have the necessary mathematical background.Numerous examples of systems from every realm of life, including the physical and biological sciences,humanities, social sciences, engineering, pre-med and pre-law, are based on the fundamental systems concepts of boundaries, components as subsystems, processes as flows of materials, energy, and messages, work accomplished, functions performed, hierarchical structures, and more.Understanding these basics enables further understanding both of how systems endure and how they may become increasingly complex and exhibit new properties or characteristics. Serves as a textbook for teaching systems fundamentals in any discipline or for use in an introductory course in systems science degree programsAddresses a wide range of audiences with different levels of mathematical sophisticationIncludes open-ended questions in special boxes intended to stimulate integrated thinking and class discussion Describes numerous examples of systems in science and societyCaptures the trend towards interdisciplinary research and problem solving
Springer-Verlag New York Inc. Plant Genome Engineering : Methods And Protocols
183.99 GBP
This volume provides readers with a collection of the latest protocols used to study plant genome editing and trait engineering.The chapters in this book are organized into five parts: genome engineering systems; machinery design and validation; delivery tools; generation and analysis of engineering materials; and crop genome engineering applications.The chapters cover topics such as methods of applying the popular CRISPR-Cas9 or CRISPR-Cas12 systems for editing genomes in different crop species, the use of small synthetic plastome for potato genome engineering, and the use of CRISPR-Cas9 for algal cell genome engineering.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Plant Genome Engineering: Methods and Protocols is a valuable tool for researchers interested in learning more about this developing and important field.
Springer-Verlag New York Inc. Complex Analysis
55.19 GBP
The present book is meant as a text for a course on complex analysis at the advanced undergraduate level, or first-year graduate level.The first half, more or less, can be used for a one-semester course addressed to undergraduates.The second half can be used for a second semester, at either level.Somewhat more material has been included than can be covered at leisure in one or two terms, to give opportunities for the instructor to exercise individual taste, and to lead the course in whatever directions strikes the instructor's fancy at the time as well as extra read ing material for students on their own.A large number of routine exer cises are included for the more standard portions, and a few harder exercises of striking theoretical interest are also included, but may be omitted in courses addressed to less advanced students.In some sense, I think the classical German prewar texts were the best (Hurwitz-Courant, Knopp, Bieberbach, etc. ) and I would recommend to anyone to look through them.More recent texts have emphasized connections with real analysis, which is important, but at the cost of exhibiting succinctly and clearly what is peculiar about complex analysis: the power series expansion, the uniqueness of analytic continuation, and the calculus of residues.
Springer-Verlag New York Inc. Psychosocial Family Interventions In Chronic Pediatric Illness
41.39 GBP
The symposium "Family Dynamics, Family Therapy, and Pediatric Medical Illness," held at Downstate Medical Center on December 12 and 13, 1980, considered the impact of life-threatening illness in children and adolescents on intrafamilial dynamics.A group of experts addressed the practical and theoretical psychological and social issues facing pediatric patients and their families when con fronting chronic and severe childhood illnesses including brain damage, cancer, hemophilia, juvenile diabetes, and heart disease.The presentations and group discussions clearly revealed the complexity of physical and psychological problems posed by the seriously ill child with chronic disease for both the health care provider and the family.The conference proceedings confirm that quality care and treatment for the ill child requires the partici pation of a variety of health care disciplines representing diverse fields of knowledge.Pediatricians, family practitioners, child psychiatrists, nurses, social workers, psychologists, nutritionists and others all have important collaborative roles to play.The symposium participants wrestled with some of the basic developmental and clinical questions: How is the ongoing development of a family altered as a result of chronic incapacitating illness in a child member?How can principles of intensive family and individ ual psychotherapy be applied during the medical treatment of life threatening illness?What are the psychological stress points during the course of a chronic medical illness?These are but a few of the issues addressed in this publication.
Springer-Verlag New York Inc. Food Safety Management : Implementing A Food Safety Program In A Food Retail Business
50.59 GBP
The goal of this book is to show how to build and manage a food safety department that is tasked with ensuring food safety within a food retail business. The experiences of the author as the head of Food and Product Safety at Chick-fil-A will be used as the model.Specifically, the book will discuss the specific components of a food safety program, the tactics needed to establish these components (forming the majority of the chapters), how to measure the success of each component, and how to influence the organization to ensure resources to support the program.The book will also focus on how to choose and work with the appropriate partners, validate the value to the business, and initiate the new component throughout the organization, including how to sustain the component within the program.Five features of this book that make it distinctive are: Most current “How to” book on leading a food safety department from the perspective of a respected national brandProvides the proper organization and methods to manage the work necessary to ensure food safety within the organization Provides the means to utilize risk-based decisions linked to business practices that accommodate a business analysis model Demonstrates step-by-step examples that can be used for continuous improvement in sustaining food safety responsibilities Provides examples on how to gain influence and obtain resources to support food safety responsibilities
Springer-Verlag New York Inc. Advanced Mathematical Methods For Scientists And Engineers I : Asymptotic Methods And Perturbation Theory
50.59 GBP
The triumphant vindication of bold theories-are these not the pride and justification of our life's work? -Sherlock Holmes, The Valley of Fear Sir Arthur Conan Doyle The main purpose of our book is to present and explain mathematical methods for obtaining approximate analytical solutions to differential and difference equations that cannot be solved exactly.Our objective is to help young and also establiShed scientists and engineers to build the skills necessary to analyze equations that they encounter in their work.Our presentation is aimed at developing the insights and techniques that are most useful for attacking new problems.We do not emphasize special methods and tricks which work only for the classical transcendental functions; we do not dwell on equations whose exact solutions are known.The mathematical methods discussed in this book are known collectively as asymptotic and perturbative analysis.These are the most useful and powerful methods for finding approximate solutions to equations, but they are difficult to justify rigorously.Thus, we concentrate on the most fruitful aspect of applied analysis; namely, obtaining the answer.We stress care but not rigor. To explain our approach, we compare our goals with those of a freshman calculus course.A beginning calculus course is considered successful if the students have learned how to solve problems using calculus.
Springer-Verlag New York Inc. Algebraic Geometry
45.99 GBP
Robin Hartshorne studied algebraic geometry with Oscar Zariski and David Mumford at Harvard, and with J.-P.Serre and A. Grothendieck in Paris. After receiving his Ph.D. from Princeton in 1963, Hartshorne became a Junior Fellow at Harvard, then taught there for several years.In 1972 he moved to California where he is now Professor at the University of California at Berkeley.He is the author of "Residues and Duality" (1966), "Foundations of Projective Geometry (1968), "Ample Subvarieties of Algebraic Varieties" (1970), and numerous research titles.His current research interest is the geometry of projective varieties and vector bundles.He has been a visiting professor at the College de France and at Kyoto University, where he gave lectures in French and in Japanese, respectively.Professor Hartshorne is married to Edie Churchill, educator and psychotherapist, and has two sons.He has travelled widely, speaks several foreign languages, and is an experienced mountain climber.He is also an accomplished amateur musician: he has played the flute for many years, and during his last visit to Kyoto he began studying the shakuhachi.
Springer-Verlag New York Inc. Sheaves In Geometry And Logic : A First Introduction To Topos Theory
59.79 GBP
We dedicate this book to the memory of J. Frank Adams. His clear insights have inspired many mathematicians, including both of us.In January 1989, when the first draft of our book had been completed, we heard the sad news of his untimely death.This has cast a shadow on our subsequent work. Our views of topos theory, as presented here, have been shaped by continued study, by conferences, and by many personal contacts with friends and colleagues-including especially O.Bruno, P. Freyd, J.M.E. Hyland, P.T. Johnstone, A. Joyal, A. Kock, F.W. Lawvere, G.E. Reyes, R Solovay, R Swan, RW. Thomason, M. Tierney, and G.C. Wraith. Our presentation combines ideas and results from these people and from many others, but we have not endeavored to specify the various original sources.Moreover, a number of people have assisted in our work by pro viding helpful comments on portions of the manuscript.In this respect, we extend our hearty thanks in particular to P.Corazza, K. Edwards, J. Greenlees, G. Janelidze, G. Lewis, and S. Schanuel.
Springer-Verlag New York Inc. Men'S Health : A Head To Toe Guide For Clinicians
82.79 GBP
This book covers issues of men’s health, including screening, diagnosis and management of common disorders and opportunities for prevention and health maintenance.Each chapter pertains to a component of the physical exam and/or organ system.Examples include appropriate survey and screening of the integument, the significance of buccal/dental integrity, tailoring cardiovascular remedies and balancing prostate cancer screening with quality of life.The book follows the methodical approach of a comprehensive wellness visit, including inventory of psychosocial factors, which significantly impact physical well-being.Justification for often overlooked topics in the review of systems, such as sexual history and satisfaction, relationship issues, and vocational fulfillment are provided.This book is written in the spirit of the rich bedside acumen and the art of healing, we must strive to protect.While informative and stimulating, this text serves to remind us of the specialized diagnostic tools we carry between our ears, and the power of healing we possess in our hands as well as the counsel and education we provide to our patients. Men’s Health: A Head to Toe Guide for Clinicians serves as an important and readily accessible resource for primary care physicians, internists and family doctors, physician’s assistants and nurse practitioners who care for adult males.
Springer-Verlag New York Inc. The Difficult Vaginal Hysterectomy : A Surgical Atlas
41.39 GBP
Knowledge of and experience with the basic technique of vaginal hysterectomy is not univers al.Each surgeon must learn to identify and appreciate the dimensions of individual variation in anatomic findings and therefore surgical technical decisions and their execu tion from one patient to another.Unexpected surgical difficulty can be predicted, but ultimately it is dealt with retrospectively.Skilled practitioners must study the particular patient and her problem comprehensively and allow for such individual variations in find ings and technical needs as are necessary to the surgical solution for that patient's problem.Recognizing these factors, Drs. Hoffman and Spellacy have orga nized and prepared a comprehensive monograph concerning this very real clinical entity.They have reviewed the experience of con temporary surgeons and blended these recommendations with their own experience in a useful compendium of surgical knowledge about this important subject.Their monograph is recommended not as a replacement for the many other fine surgical texts available to the reader but as a supplement to the surgeon's library.It is for those surgeons who, having mastered the basic techniques, are in terested in extending the frontiers of personal knowledge of this provocative subject and safely broadening the indications for effec tive surgery and reconstruction.David H. Nichols, M.D., F.A.C.S., F.A.C.O.G.
Springer-Verlag New York Inc. Case Studies Of Near Misses In Clinical Anesthesia
64.39 GBP
All anesthesiologists eventually face the fear of a “near miss,” when a patient’s life has been put at risk. Learning from the experience is crucial to professionalism and the ongoing development of expertise.Drawing on forty-plus years of practice in major metropolitan hospitals in the United States, Norway, and South Africa, John Brock-Utne, MD presents 80 carefully selected cases that provide the basis for lessons and tips to prevent potential disaster. The cases emphasize problem-centered learning and span a broad range of topics—from an outbreak of operating room infection (could it be the anesthesia equipment?), complications of fiberoptic intubations, and problems with epidural drug pumps, to performing an urgent tracheostomy for the first time, working with an aggressive surgeon, and what to do when a patient falls off the operating table during surgery. 80 true-story clinical “near misses” never before published, ideal for problem-centered learning, recommendations, references, and discussions accompany most cases, rich basis for teaching discussions both in or out of the operating room, settings include sophisticated as well as rudimentary anesthetic environments, complements the author’s other case book, Clinical Anesthesia: Near Misses and Lessons Learned (Springer, 2008).
Springer-Verlag New York Inc. Groups And Symmetry
41.39 GBP
Groups are important because they measure symmetry.This text, designed for undergraduate mathematics students, provides a gentle introduction to the highlights of elementary group theory.Written in an informal style, the material is divided into short sections each of which deals with an important result or a new idea.Throughout the book, the emphasis is placed on concrete examples, many of them geometrical in nature, so that finite rotation groups and the seventeen wallpaper groups are treated in detail alongside theoretical results such as Lagrange's theorem, the Sylow theorems, and the classification theorem for finitely generated abelian groups.A novel feature at this level is a proof of the Nielsen-Schreier theorem, using group actions on trees.There are more than three hundred exercises and approximately sixty illustrations to help develop the student's intuition.
Springer-Verlag New York Inc. Measure Theory
40.47 GBP
Useful both as a text for students and as a source of reference for the more advanced mathematician, this book presents a unified treatment of that part of measure theory which is most useful for its application in modern analysis.The text is suitable for the beginning graduate student as well as the advanced undergraduate.
Springer-Verlag New York Inc. Mathematical Control Theory
41.39 GBP
This self-contained volume surveys three decades of mathematical control theory and at the same time describes how the work of Roger Brockett shaped and influenced its development.Nine survey articles written by leading experts in the field, who have also been closely associated with Roger Brockett at various stages in his career, treat the subject cohesively and in depth.This volume will provide an important reference for graduate students and researchers, as well as for mathematicians, engineers and scientists whose work involves concepts and the language of control and systems theory.
Springer-Verlag New York Inc. Methods For Analyzing Large Neuroimaging Datasets
41.39 GBP
This Open Access volume explores the latest advancements and challenges in standardized methodologies, efficient code management, and scalable data processing of neuroimaging datasets.The chapters in this book are organized in four parts.Part One shows the researcher how to access and download large datasets, and how to compute at scale.Part Two covers best practices for working with large data, including how to build reproducible pipelines and how to use Git.Part Three looks at how to do structural and functional preprocessing data at scale, and Part Four describes various toolboxes for interrogating large neuroimaging datasets, including machine learning and deep learning approaches.In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and comprehensive, Methods for Analyzing Large Neuroimaging Datasets is a valuable resource that will help researchers obtain the practical knowledge necessary for conducting robust and reproducible analyses of large neuroimaging datasets.
Springer-Verlag New York Inc. Atomic Layer Deposition For Semiconductors
128.79 GBP
This edited volume discusses atomic layer deposition (ALD) for all modern semiconductor devices, moving from the basic chemistry of ALD and modeling of ALD processes to sections on ALD for memories, logic devices, and machines.The section on ALD for memories covers both mass-produced memories, such as DRAM and Flash, and emerging memories, such as PCRAM and FeRAM.The section on ALD for logic devices covers both front-end of the line processes and back-end of the line processes.The final section on ALD for machines looks at toolsets and systems hardware.Each chapter provides the history, operating principles, and a full explanation of ALD processes for each device.
Springer-Verlag New York Inc. The Purchasing Chessboard : 64 Methods To Reduce Costs And Increase With Suppliers
50.59 GBP
The bestselling Purchasing Chessboard® concept, used by hundreds of corporations worldwide to reduce costs and increase value with suppliers, is the topic of this successful professional book now published in its third edition.The 64 squares on the Purchasing Chessboard provide a wealth of methods that can be applied either individually or in combination. And because many of these methods are not customarily used by procurement, the Purchasing Chessboard is also the perfect tool for helping procurement professionals to think and act outside the box and find new solutions.A well tested concept that works across all industries and all categories in any given situation, it is little wonder that business leaders and procurement professionals alike are excited by, and enjoy strategizing around, the Purchasing Chessboard.It encourages greater rigor and creativity and the building of world class capabilities. The explosive growth in analytics and the rise in the number of specialists in procurement practice have taken the application of the Purchasing Chessboard to new levels.This third edition of the book includes a rich assortment of case examples to reflect the lessons learned across geographies and industries.Some of the chapters have also been updated to accurately reflect these trends.
Springer-Verlag New York Inc. Representation Theory : A First Course
50.59 GBP
The primary goal of these lectures is to introduce a beginner to the finite dimensional representations of Lie groups and Lie algebras.Since this goal is shared by quite a few other books, we should explain in this Preface how our approach differs, although the potential reader can probably see this better by a quick browse through the book.Representation theory is simple to define: it is the study of the ways in which a given group may act on vector spaces.It is almost certainly unique, however, among such clearly delineated subjects, in the breadth of its interest to mathematicians.This is not surprising: group actions are ubiquitous in 20th century mathematics, and where the object on which a group acts is not a vector space, we have learned to replace it by one that is {e. g. , a cohomology group, tangent space, etc. }. As a consequence, many mathematicians other than specialists in the field {or even those who think they might want to be} come in contact with the subject in various ways.It is for such people that this text is designed. To put it another way, we intend this as a book for beginners to learn from and not as a reference.This idea essentially determines the choice of material covered here.As simple as is the definition of representation theory given above, it fragments considerably when we try to get more specific.
Springer-Verlag New York Inc. Complex Analysis
50.59 GBP
The book provides an introduction to complex analysis for students with some familiarity with complex numbers from high school.It conists of sixteen chapters. The first eleven chapters are aimed at an Upper Division undergraduate audience.The remaining five chapters are designed to complete the coverage of all background necessary for passing PhD qualifying exams in complex analysis.Topics studied in the book include Julia sets and the Mandelbrot set, Dirichlet series and the prime number theorem, and the uniformization theorem for Riemann surfaces.The three geometries, spherical, euclidean, and hyperbolic, are stressed.Exercises range from the very simple to the quite challenging, in all chapters.The book is based on lectures given over the years by the author at several places, including UCLA, Brown University, the universities at La Plata and Buenos Aires, Argentina; and the Universidad Autonomo de Valencia, Spain.